Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides.
نویسندگان
چکیده
Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2'-fucosyllactose (2'FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2'FL and 3FL bound at the equivalent HBGA pockets on the norovirus capsid using X-ray crystallography. Our data revealed that 2'FL and 3FL structurally mimic HBGAs. These results suggest that 2'FL and 3FL might act as naturally occurring decoys in humans.
منابع مشابه
Oligosaccharides and glycoconjugates of human milk could protect breast-fed infants against norovirus intestinal infections
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عنوان ژورنال:
- Journal of virology
دوره 90 9 شماره
صفحات -
تاریخ انتشار 2016